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Search Results for " mycobacterium tuberculosis "

140

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38359	Dup-721	Antibacterial	Microbiology/Virology
	DuP-721 是广谱的口服有效的抗菌剂，可以抑制多种临床敏感和耐药细菌，特别是结核杆菌M. tuberculosis。
T9734	InhA-IN-2	CDK	Cell Cycle/Checkpoint
	InhA-IN-2直接抑制 InhA，不需要过氧化氢酶过氧化物酶 KatG 的激活。
T7342	BM212	Antibacterial	Microbiology/Virology
	BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌，抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。
T10411	AU1235	Antibacterial	Microbiology/Virology
	AU1235是金刚烷脲，是一种MmpL3抑制剂。结核分枝杆菌蛋白MmpL3在细胞壁合成中起重要作用，它影响海藻糖单支霉菌酸酯跨内膜转运。
T8694	ML406	Antibacterial; Antibiotic	Microbiology/Virology
	ML406 是一种小分子探针，通过抑制M.tuberculosisBioA(DAPA 合酶) 显示出抗结核活性，IC50为 30 nM。
T5315	TCA1 TCA-1,TCA 1	Antibacterial; Antibiotic	Microbiology/Virology
	TCA1 (TCA 1) 是一种小分子，具有抗耐药性和持续性结核病的活性。
T0827	Cefsulodin sodium Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠	Antibacterial; Antibiotic	Microbiology/Virology
	Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素，对缘脓杆菌和肠杆菌有活性。
T77730	QST4	Antifungal	Microbiology/Virology
	QST4 具有抗结核、抗真菌活性，在结核分枝杆菌 Mycobacterium tuberculosis H37Rv 中的 MIC 值为 6.25 μM。
T3642	TBA-354 TBA 354	Antibacterial; Antibiotic	Microbiology/Virology
	TBA-354 有抗结核作用，对结核分枝杆菌 H37Rv 菌株具有活性。
T61411	InhA-IN-4	Antibacterial	Microbiology/Virology
	InhA-IN-4 (TU14) 是一种有效的结核分枝杆菌InhA(烯酰 ACP 还原酶) 抑制剂，具有潜在的抗癌和抗增殖活性，可用于研究结核分枝杆菌感染。
T60866	InhA-IN-3	Antibacterial	Microbiology/Virology
	InhA-IN-3 (TU13) 是一种有效的结核分枝杆菌InhA(烯酰 ACP 还原酶) 抑制剂，具有潜在的抗癌和抗增殖活性，可用于研究结核分枝杆菌感染。
T60073	Antimycobacterial agent-4 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide	Antibacterial	Microbiology/Virology
	Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) 对结核分枝杆菌具有抗菌活性。
T3582	BTZ043	Antibacterial; Antibiotic; DprE1	Microbiology/Virology; Others
	BTZ043 是一种 DprE1 的抑制剂，它对结核分枝杆菌 H37Rv 和耻垢分枝杆菌具有纳摩尔杀菌活性，MIC 值分别为 2.3 nM 和 9.2 nM。
T9830	GSK2556286 GSK286	Antibacterial	Microbiology/Virology
	GSK2556286 (GSK286) 是一种具有口服活性的结核分枝杆菌 (M. tuberculosis) 抑制剂。GSK2556286 对人巨噬细胞 (macrophages) 生长具有抑制作用，IC50值为 0.07 μM。GSK2556286对多重耐药 (MDR) 或广泛耐药 (XDR) 和药物敏感 (DS) 结核分枝杆菌均有效。
T72576	Transketolase-IN-4	Antibacterial	Microbiology/Virology
	Transketolase-IN-4 是一种转酮酶抑制剂，IC50值为3.9 μM。Transketolase-IN-4 对结核分枝杆菌 DXS 有抑制作用，IC50 为 114.1 μM。 Transketolase-IN-4 抑制 SW620、LS174T 和 MIA PaCa-2 的肿瘤细胞增殖。
T27453	GSK1733953A DG70	Antibacterial	Microbiology/Virology
	GSK1733953A 可作为一种小分子结核分枝杆菌呼吸抑制剂，对 MenG 活性有抑制作用，IC50 值为 2.6 ± 0.6 μM。GSK1733953A 是一种具有选择性的联苯苯甲酰胺，对结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化有抑制作用，对结核分枝杆菌H4Rv的MIC为8.37 μg/ml，对耐药菌株的MIC为1.2至9.6 μg/ml。GSK1733953A 是治疗结核病的候选化合物。
T13346L	WQ3810 TFA WQ3810 TFA(888032-58-4 Free base),KPI-10 TFA	Antifungal	Microbiology/Virology
	WQ3810 TFA 是一种可口服的氟喹诺酮，具有抗菌活性，对结核分枝杆菌有抑制作用，抑制氧氟沙星耐药麻风分枝杆菌的 DNA 旋转酶活性。
T11497	Ganfeborole HCl GSK3036656 HCl,GSK656 HCl	Antibacterial	Microbiology/Virology
	Ganfeborole HCl (GSK3036656 HCl) 是一种具有抗结核活性的小分子化合物，是结核分枝杆菌（Mtb）亮氨酰-tRNA 合成酶（LeuRS；IC50：0.2 μM）的抑制剂。
T77683	Methyl quinoline-2-carboxylate Methyl 2-quinolinecarboxylate	Antibacterial	Microbiology/Virology
	Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) 对结合结核杆菌具有抑制作用。
T78745	Mtb-IN-2	Antibiotic	Microbiology/Virology
	Mtb-IN-2 是一种具有抗菌活性和低毒性的结核分枝杆菌(Mtb)的小分子化合物，干预蛋氨酸代谢过程，可用于研究结核病。
T2585	Bedaquiline R207910,TMC207,贝达喹啉	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
T12231	NITD-349	Others; Antibacterial	Microbiology/Virology; Others
	NITD-349 是MmpL3的抑制剂，它对毒性结核分枝杆菌 H37Rv 显示出高效的抗分枝杆菌活性，MIC50 为 23 nM。
T67827	Urease Inhibitor 07	Others	Others
	Urease Inhibitor 07 是一种异取代金属蛋白酶抑制剂，对结核分枝杆菌H37Rv 菌株的潜在活性。
T21023	Bedaquiline fumarate TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline fumarate (TMC207) 是二芳基喹啉抗生素，作用于 ATP 合成酶，常用于结核杆菌感染的研究。
T1940	BTB06584	RAAS; ATPase	Endocrinology/Hormones; Membrane transporter/Ion channel
	BTB06584 是选择性依赖 IF1 的线粒体F1Fo-ATPase 抑制剂，可延迟缺血性细胞死亡。
T0020	Sodium 4-aminosalicylate dihydrate 对氨基水杨酸钠二水合物,Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt	Free radical scavengers; NF-κB; Antibacterial; Antibiotic	Microbiology/Virology; NF-κB; oxidation-reduction
	Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) 是一种抗耐药性结核化合物。
T67765	MenA-IN-2	Others	Others
	MenA-IN-2是一种有效的 1,4-二羟基-2-萘甲酸酯异戊二烯转移酶 (MenA) 抑制剂，对 MenA 的 IC50 值为 22 µM，对结核分枝杆菌 (Mtb) 的 GIC50 值为 10 µM。MenA-IN-2 Mtb 的持续传播具有抑制作用。
T7877	Thiacetazone 氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Thiacetazone (Diazam) 是一种氨基硫脲抗结核剂，也是一种具有口服活性抗生素。它具有抗菌作用，可抑制结核分枝杆菌 H37Rv 的生长，MIC 值为 0.1 μg/mL。
T5400	Q203 IAP6,Telacebec	Antibacterial; Antibiotic	Microbiology/Virology
	Q203 (Telacebec)是一种中氮杂吡啶酰胺。在培养基中抑制结核分枝杆菌H37Rv 活性的MIC50值为2.7 nM。
T40520	Thiophene-2 Thiophene-2,TP2
	Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
T11594	I2906	Others	Others
	I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
T27477	GSK366A
	GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6.
T69470	HC103A
	HC103A is an inhibitor of Mycobacterium tuberculosis DosRST signaling and persistence.
T11817	Lansoprazole Sulfide D4	Proton pump	Membrane transporter/Ion channel
	Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole.
T26733	B 746 B-746,B746
	B 746 is an antibacterial agent primarily. B 746 is used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance.
T20799	Lobenzarit Lobenzaritum
	Lobenzarit, an immunomodulator, is most frequently used to treat arthritis. Its chemical scaffold has been repurposed to tryptophan biosynthesis in Mycobacterium tuberculosis
T25468	GSK1829820A GSK-1829820-A,GSK 1829820A,GSK 1829820 A,GSK-1829820A
	GSK1829820A is a Mycobacterium tuberculosis H37Rv non-cytotoxic inhibitor.
T34177	Pseudopterosin E
	Pseudopterosin E can act towards Mycobacterium tuberculosis and other pathogens.
T29701	AG 85 AG85,AG-85
	AG 85 is a major secretion protein of Mycobacterium tuberculosis.
T24765	SB-790594-A SB790594A,SB 790594 A
	SB-790594-A is a non-cytotoxic Mycobacterium tuberculosis H37Rv inhibitor.
T24397	ZTB23(R) ZTB 23(R),ZTB-23(R)
	ZTB23(R) is the first potent and selective inhibitor of Mycobacterium tuberculosis Zmp1.
T31688	Ethambutol, (R,R)- L-Ethambutol
	Ethambutol, (R, R)- can be used to treat tuberculosis. It is usually used in combination with other tuberculosis medications. It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii.
T79511	Tuberculosis inhibitor 8
	Tuberculosis inhibitor 8 (compound 3b) 是 3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物，具有针对结核分枝杆菌 (MIC90为 0.69 μM) 和海洋分枝杆菌 (MIC90为 0.69 μM) 的高抗菌活性。
T71727	HC102A
	HC102A is an inhibitor of Mycobacterium tuberculosis DosRST signaling and persistence.
T61096	Antibacterial agent 95
	Antibacterial agent 95 (2-(quinoline-4-methoxy) acetamide), a new antituberculotic agent, exhibited a minimum inhibitory concentration (MIC) of only 0.3 μM against the reference strain of Mycobacterium tuberculosis H37Rv. Additionally, it effectively suppressed the growth of Mycobacterium tuberculosis in the macrophage model of tuberculosis infection.
T110951	Compound F0447-0245
	Antitubercular agent-33 是一种 2-氨基噻唑衍生物，对于结核分枝杆菌 (Mycobacterium tuberculosis,Mtb)显示出有效的抗结核活性。
T70671	IC2418
	IC2418 is an MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis.
T11983	MDRTB-IN-1	Others	Others
	MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv(MIC90 :10.5 μM).
T29527	ABT-255 ABT 255,ABT255,UNII-YA04O24J4T
	ABT-255 is a novel 2-pyridone antimicrobial agent for the treatment of tuberculosis. Both drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis showed efficacy in vitro and in vivo.
T27848	LP10 LP-10,LP 10
	LP10 is a reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1 and a Potent type II inhibitor of Trypanosoma cruzi CYP51.

化合物

Cat.No: T38359

Target: Antibacterial

Cat.No: T9734

Target: CDK

Cat.No: T7342

Target: Antibacterial

Cat.No: T10411

Target: Antibacterial

Cat.No: T8694

Target: Antibacterial, Antibiotic

Cat.No: T5315

Synonym: TCA-1,TCA 1

Target: Antibacterial, Antibiotic

Cefsulodin sodium

Cat.No: T0827

Synonym: Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠

Target: Antibacterial, Antibiotic

Cat.No: T77730

Target: Antifungal

Cat.No: T3642

Synonym: TBA 354

Target: Antibacterial, Antibiotic

Cat.No: T61411

Target: Antibacterial

Cat.No: T60866

Target: Antibacterial

Antimycobacterial agent-4

Cat.No: T60073

Synonym: 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide

Target: Antibacterial

Cat.No: T3582

Target: Antibacterial, Antibiotic, DprE1

Cat.No: T9830

Synonym: GSK286

Target: Antibacterial

Transketolase-IN-4

Cat.No: T72576

Target: Antibacterial

Cat.No: T27453

Synonym: DG70

Target: Antibacterial

Cat.No: T13346L

Synonym: WQ3810 TFA(888032-58-4 Free base),KPI-10 TFA

Target: Antifungal

Ganfeborole HCl

Cat.No: T11497

Synonym: GSK3036656 HCl,GSK656 HCl

Target: Antibacterial

Methyl quinoline-2-carboxylate

Cat.No: T77683

Synonym: Methyl 2-quinolinecarboxylate

Target: Antibacterial

Cat.No: T78745

Target: Antibiotic

Cat.No: T2585

Synonym: R207910,TMC207,贝达喹啉

Target: Antibacterial, Antibiotic

Cat.No: T12231

Target: Others, Antibacterial

Urease Inhibitor 07

Cat.No: T67827

Target: Others

Bedaquiline fumarate

Cat.No: T21023

Synonym: TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323

Target: Antibacterial, Antibiotic

Cat.No: T1940

Target: RAAS, ATPase

Sodium 4-aminosalicylate dihydrate

Cat.No: T0020

Synonym: 对氨基水杨酸钠二水合物,Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt

Target: Free radical scavengers, NF-κB, Antibacterial, Antibiotic

Cat.No: T67765

Target: Others

Cat.No: T7877

Synonym: 氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil

Target: Others, Antibacterial, Antibiotic

Cat.No: T5400

Synonym: IAP6,Telacebec

Target: Antibacterial, Antibiotic

Cat.No: T40520

Synonym: Thiophene-2,TP2

Cat.No: T11594

Target: Others

Cat.No: T27477

Cat.No: T69470

Lansoprazole Sulfide D4

Cat.No: T11817

Target: Proton pump

Cat.No: T26733

Synonym: B-746,B746

Cat.No: T20799

Synonym: Lobenzaritum

Cat.No: T25468

Synonym: GSK-1829820-A,GSK 1829820A,GSK 1829820 A,GSK-1829820A

Pseudopterosin E

Cat.No: T34177

Cat.No: T29701

Synonym: AG85,AG-85

Cat.No: T24765

Synonym: SB790594A,SB 790594 A

Cat.No: T24397

Synonym: ZTB 23(R),ZTB-23(R)

Ethambutol, (R,R)-

Cat.No: T31688

Synonym: L-Ethambutol

Tuberculosis inhibitor 8

Cat.No: T79511

Cat.No: T71727

Antibacterial agent 95

Cat.No: T61096

Compound F0447-0245

Cat.No: T110951

Cat.No: T70671

Cat.No: T11983

Target: Others

Cat.No: T29527

Synonym: ABT 255,ABT255,UNII-YA04O24J4T

Cat.No: T27848

Synonym: LP-10,LP 10

Cat. No.	Product Name	Target	Signaling Pathways
T1426	Pyrazinamide Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺	Antibacterial; Antibiotic; Autophagy; Fatty Acid Synthase	Autophagy; Metabolism; Microbiology/Virology
	Pyrazinamide (Pyrazinecarboxamide) 是一种口服抗结核类抗生素。它是一种前药，通过结核分枝杆菌pncA 基因编码的 PZase/烟酰胺酶转化为活性吡嗪酸形式。
TN1466	Canthin-6-one NSC 103003	Antifungal	Microbiology/Virology
	Canthin-6-one(NSC 103003) 是一种从 Allium neapolitanum 分离出来的生物碱，具有抗菌活性，对结核分枝杆菌具有抑制作用。
TN2279	Totarol (+)-Totarol,桃柁酚	Antibacterial; Antifection	Microbiology/Virology
	Totarol ((+)-Totarol) 对几种致病性革兰氏阳性细菌、结核分枝杆菌具有抗菌作用。
TN5503	Linaroside	Antibacterial	Microbiology/Virology
	Linaroside 在 6.25 microg mL(-1) 浓度下对结核分枝杆菌、菌株 H(37)Rv 的抗分枝杆菌活性表现出 30%的抑制作用。
T5041	Faropenem sodium 法罗培南,法罗培南钠	Antibacterial; Antibiotic	Microbiology/Virology
	Faropenem sodium 是一种口服生物可利用的青霉烯类抗生素，能有效杀灭结核分枝杆菌，治疗结核病和社区获得性肺炎。
T5722	Nevadensin Pedunculin,石吊兰素,5,7-二羟基-6,8,4'-三甲氧基黄酮	Anti-infection; Antibacterial	Microbiology/Virology
	Nevadensin 是一种重要的草本成分，可抑制雌二醇的生物活化。它具有抗结核分枝杆菌、镇咳、抗炎、抗高血压等多种药理作用。
TN2086	Piperlotine A	Antibacterial	Microbiology/Virology
	Piperlotine A 是一种可从罗洛胡椒中提取得到的生物碱，具有抗血小板聚集活性。Piperlotine A 在体外试验中显示出对结核分枝杆菌的抑制作用，MIC 值为 50 ug/mL。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN5684	5,6-Desmethylenedioxy-5-methoxyaglalactone
	5,6-Desmethylenedioxy-5-methoxyaglalactone is cytotoxic to small cell lung cancer (NCI-H187) cell line. It has antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra.
TN5657	Goniotriol
	Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H
T75564	Pomolic acid 3-acetate
	Pomolic acid 3-acetate 是一种抗结核 (antitubercular) 剂，对 Mycobacterium tuberculosisH37Rv 的 MIC 为 32 μM。
TN5648	Porson
	Porson exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 40.0 μg/mL.
TN4944	Santamarine	Caspase	Apoptosis; Proteases/Proteasome
	Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity against clinical strains of Mycobacterium tuberculosis.
TN4336	Isothymusin	Antifection	Microbiology/Virology
	Isothymusin( MIC= 200 microg/mL) exhibits inhibition activity against Mycobacterium tuberculosis. It ( IC50=7.7 microg/mL ) exhibits antioxidant activity against the radical scavenging ability of DPPH.
TN3924	Eichlerialactone	Others	Others
	Eichlerialactone and ethyl eichlerianoate show antimycobacterial activity against mycobacterium tuberculosis H37Ra, with minimum inhibitory concentration in the range of 25-50ug/mL; eichlerialactone exhibits good antibacterial activity against both the Gr
TN4953	Sativan 三叶草	Antifection	Microbiology/Virology
	Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL.
TN4776	Physalin D	TNF; Antifection	Apoptosis; Microbiology/Virology
	Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin D displays considerable cytotoxicity against several cancer cell lines. It
TN3560	Cabralealactone	Antifection	Microbiology/Virology
	Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line.
TN3559	Cabraleahydroxylactone	HSV	Microbiology/Virology
	Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL).
T75631	Ganorbiformin B
	Ganorbiformin B是一种具有与灵芝酸相同羊毛甾烷骨架的羊毛甾烷三萜类化合物。其C-3差向异构体灵芝酸T对结核分枝杆菌H37Ra显示出强抗分枝杆菌活性。
TN3557	Cabraleadiol	ATPase; Antifection	Membrane transporter/Ion channel; Microbiology/Virology
	Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi
T75633	(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid
	(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) 为具有抗结核活性的化合物，对结核分枝杆H37Ra的最小抑菌浓度（MIC）为12.5 μg/mL，并展现出对Vero细胞的细胞毒性，其半数抑制浓度（IC50）值为32 μM[1]。
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
T72742	(-)-Pinocembrin (-)-乔松素
	(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性，无论是休眠还是活跃期，其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂，(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系，IC50 值范围为 1.88 至 11.00 mg/mL。
TN1694	Gliotoxin	Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Gliotoxin 是一种次生代谢产物，由A. fumigatus 分泌，可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性，从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度，调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...
TN1378	α-Viniferin ALPHA-VINIFERIN,Alpha-葡萄素	P450; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	α-Viniferin 也称为2-芳基苯并呋喃类黄酮，是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性

天然产物

Cat.No: T1426

Synonym: Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺

Target: Antibacterial, Antibiotic, Autophagy, Fatty Acid Synthase

Cat.No: TN1466

Synonym: NSC 103003

Target: Antifungal

Cat.No: TN2279

Synonym: (+)-Totarol,桃柁酚

Target: Antibacterial, Antifection

Cat.No: TN5503

Target: Antibacterial

Faropenem sodium

Cat.No: T5041

Synonym: 法罗培南,法罗培南钠

Target: Antibacterial, Antibiotic

Cat.No: T5722

Synonym: Pedunculin,石吊兰素,5,7-二羟基-6,8,4'-三甲氧基黄酮

Target: Anti-infection, Antibacterial

Cat.No: TN2086

Target: Antibacterial

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

5,6-Desmethylenedioxy-5-methoxyaglalactone

Cat.No: TN5684

Cat.No: TN5657

Pomolic acid 3-acetate

Cat.No: T75564

Cat.No: TN5648

Cat.No: TN4944

Target: Caspase

Cat.No: TN4336

Target: Antifection

Eichlerialactone

Cat.No: TN3924

Target: Others

Cat.No: TN4953

Synonym: 三叶草

Target: Antifection

Cat.No: TN4776

Target: TNF, Antifection

Cabralealactone

Cat.No: TN3560

Target: Antifection

Cabraleahydroxylactone

Cat.No: TN3559

Target: HSV

Ganorbiformin B

Cat.No: T75631

Cat.No: TN3557

Target: ATPase, Antifection

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid

Cat.No: T75633

Cat.No: TN5014

Target: Antifection, HSV

(-)-Pinocembrin

Cat.No: T72742

Synonym: (-)-乔松素

Cat.No: TN1694

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Cat.No: T38330

Cat.No: TN1378

Synonym: ALPHA-VINIFERIN,Alpha-葡萄素

Target: P450, NO Synthase, Prostaglandin Receptor

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